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    When transplanted into a mouse model of liver disease (‘FAH –/–’), these cells partially rescued the liver phenotype. their numerous biomedical implications in studies of hepatitis, drug testing, as well as transplantation for chronic liver diseases, scientists around the world have unsuccessfully attempted for decades to regenerate primary liver cells.

    We also work with pancreas cells and diseased human liver cells in culture, and are testing how well our models can represent in vivo pathology. (2016) Cellular plasticity in the adult liver and stomach. We have recently achieved that challenge by transplanted into a mouse model of an inherited liver disease, which resembles the Tyrosinemia type I human liver disease, the cultured and transplanted liver cells continued to grow in the recipient livers and alleviated the pathology of the disease by prolonging the survival of the transplanted mice, thus proving their therapeutic potential.

    Our goal is to understand the activation mechanism in order to harness it for therapeutic strategies. • Huch M and Dollé L (2016) The plastic cellular states of liver cells: Are Ep CAM and Lgr5 fit for purpose? Our aim is to understand the molecular mechanism by which liver or other adult cells sense the damage infringed to the tissue and start the repairing process.

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